Led by Pastor Monsignor John J. O'Keefe, St. Margaret has been serving the Pearl River community since 1900. The church established the St. Margaret School in 1953 and the two entities have been working closely together ever since. The church offers mass seven days a week, as well as a variety of programs for children and adults such as Bible study, "Catholic Golden Age," CYO Basketball, a parenting center, thrift shop and Project Caring. Additionally, bingo is held every Tuesday and Thursday evening.